According to the expression of canonical lineage markers from the scRNA-seq profiles, these cells were grouped in fifteen cell clusters, which were termed CD8+ T cells, CD4+ T cells, fibroblasts, B cells, mononuclear leucocytes, macrophage, breast cancer cells, plasma cells, naive T cells, natural killer cells, endothelial cells, intrinsic lymphocytes, natural killer T cells, neutrophils and epithelial cells [27]. The gene discussed is CD4; the disease is breast carcinoma.