And within the SAT of the young and the elderly, we identified seven genes whose expression are dramatically altered, further investigation were carried out on these genes, in which we found all seven of these gene’s chromatin open regions contain thyroid hormone binding site, and were able to be stimulated by TH, suggesting that thyroid signaling may be linked with the functional change of SAT in the senescence process. The gene discussed is TH; the disease is thyroid gland disorder.