A next-generation sequencing (NGS) test has been performed in the proband, utilizing a gene panel covering 23 relevant genes implicated in polyposis and colorectal cancer (ACVRL1, APC, AXIN2, BMPR1A, ENG, EPCAM, GREM1, MLH1, MLH3, MSH2, MSH3, MSH6, MUTYH, NTHL1, PMS2, POLD1, POLE, PTEN, RNF43, SMAD4, STK11, TSC1, and TSC2). Here, AXIN2 is linked to polyposis.