In terms of LncRNAs, SNHG1 repressed the transcription of Cyclin Dependent Kinase Inhibitor 1A (CDKN1A) and CDKN2B in the nucleus by enhancing EZH2-mediated H3K27me3 in the promoters of CDKN1A and CDKN2B, leading to de-repression of the cell cycle, thereby promoting HCC cell growth, cell cycle progression, metastasis and epithelial–mesenchymal transition (EMT) [32]. This evidence concerns the gene SNHG1 and hepatocellular carcinoma.