To further investigate the possibility of individualized treatment of EZH2 in HCC patients, we examined the relationship between risk score and IC50 of various drugs used in clinical treatment of HCC, including Sorafenib, 5-Fluorouracil, Doxorubicin, Etoposide, Paclitaxel, and Vinorelbine. The gene discussed is EZH2; the disease is hepatocellular carcinoma.