SNHG12 regulated the SNHG12/miR-199a/b-5p pathway through a ceRNA mechanism, thereby reducing the inhibitory effect on Mixed Lineage Kinase 3 (MLK3, its expression was upregulated in tumor tissues and was associated with tumor progression and metastasis), thus enhanced expression of MLK3 and its downstream effectors in the NF-κB pathway, and finally promoted the occurrence and development of HCC [34]. Here, NFKB1 is linked to hepatocellular carcinoma.