Several aVMCs mapped to genes implicated in age-related, female-specific diseases. For example, one aVMCs (cg07876586) mapped to the progesterone receptor membrane component 1 (PGRMC1), a gene associated with female-specific cancer types such as breast cancer [47] and ovarian cancer [48] (Additional file 1: Fig. S4, Additional file 2: Table S6). This evidence concerns the gene PGRMC1 and ovarian cancer.