Another aVMC (cg23501813) mapped to Bruton’s tyrosine kinase (BTK) which is a key mediator of B cell receptor signaling and is linked to age-related autoimmune diseases common in females such as rheumatoid arthritis (RA) [49] and systemic lupus erythematosus (SLE) [50] (Additional file 2: Table S6). Here, BTK is linked to autoimmune disease.