Moreover, statistical analysis showed that low expression of RNF173 was significantly associated with adverse clinical pathological features, including tumor number (p = 0.03), tumor capsule (p = 0.017), tumor differentiation degree (p < 0.001), and Barcelona Clinic Liver Cancer (BCLC) stage (p = 0.022; Table 1). The gene discussed is MARCHF3; the disease is liver cancer.