In view of the fact that Ragulator-mediated malignant biology of PDAC has not been reported so far, and according to the above functional properties of Ragulator, we speculated that Ragulator complex containing LAMTOR2 was dysregulated in PDAC cells, which can act as a cancer promoting factor to maintain the malignant phenotypes of PDAC by activating mTOR. Here, MTOR is linked to cancer.