CCT4 and diabetic kidney disease: In contrast, proteins overabundant in glomeruli from PTDM patients compared to those from T2DM patients included CCT4, which is a component of the T-complex protein ring that has been proposed as a biomarker of glomerular hyperfiltration [30, 31], and CNDP2, which is possibly also associated with diabetic kidney disease [32] (Fig. 5A).