BMP7 and cancer: For example, in different models of cancer, BMP-7 has been shown to oppose development of cancer metastasis (Na et al. 2009; Shen et al. 2018), via promoting mesenchymal to epithelial transition of cancerous cells, as well as inhibiting telomerase activity in cancer cells, thereby reducing telomere length and inducing cell senescence in cancer cells (Lu et al. 2017; Ning et al. 2019).