Also in HIV-associated neuropathy (HIVAN), higher BMP-7 was associated with less fibrosis and low risk for HIVAN to transition to ESRD, while increased levels of TGF-β1 and TGF-β2 were identified as biomarkers for increased risk of ESRD (Naicker et al. 2021). The gene discussed is TGFB1; the disease is HIV-associated nephropathy.