To explore the potential of O304 to ameliorate hyperglycemia in the context of severe insulin resistance, 6 w old male leptin receptor-deficient db/db mice were treated with O304 formulated in the diet at a concentration of 0.5 or 1.0 mg/g O304, denoted O304(0.5) and O304(1.0), respectively, for 9 w. This evidence concerns the gene LEPR and Insulin resistance.