Although previous studies have shown that NT-proBNP levels might have started to decline 48 h after onset, a pooled data meta-analysis supported these findings that BNP/NT-proBNP levels were noticeably raised in cardioembolic stroke up to 72 h after the stroke onset8 and may remain elevated at day 6 in acute ischemic stroke26. This evidence concerns the gene NPPB and stroke disorder.