KCTD12 and glioblastoma: A negative correlation was observed between KCTD12 and TMB in GBM (R = − 0.289, P = 0.000), LUAD (R = − 0.110, P = 0.0131), HNSC (R = − 0.143, P = 0.001), CHOL (R = − 0.410, P = 0.016), and other tumors (Fig. 6a).