In addition to the MLL-AF4-unique enhancers, some enhancer loci appeared active across a broader subset of ALL cell lines (cluster 3), and others appeared to be more highly active in non-MLLr cell lines (clusters 1 and 2), for example, at TNFRSF14 (Supplementary Fig. 2d, right). This evidence concerns the gene KMT2A and acute lymphoblastic leukemia.