The expression in TRIB3 of DLBCL cell lines, including ABC subtype cell lines (HBL-1, SUDHL2) and GCB subtype cell lines (SUDHL4), were higher than normal B cell lines (GM12878) (P < 0.05), and ABC subtype cell lines were higher than GCB subtype (P < 0.05). The gene discussed is TRIB3; the disease is diffuse large B-cell lymphoma.