TNF and Insulin resistance: The KEGG pathway analysis showed that protein processing in ER, fluid shear stress, tumor necrosis factor (TNF) signaling pathway, atherosclerosis, and insulin resistance were enriched (Fig. 3B). More details of the top 50 significant items of GO enrichment analysis and KEGG pathway analysis (Ref: 231,102) could be shown in Supplementary Tables S3 and S4.