We overlaid these 4 modules with FRGs and found that 8 FRGs (LCE2C, NOS2, AKR1C3, CAV1, MMD, LINC00618, SNCA, SLC7A11) were closely related to the disease state of keratoconus (Fig. 3D). This evidence concerns the gene SLC7A11 and keratoconus.