CALR and neoplasm: Immunogenic cell death (ICD) is a promising approach to activate the immunogenicity of tumor cells for enhanced antitumor immune responses, during which tumor cells secrete immunostimulatory damage-associated molecular patterns (DAMPs) including surface-exposed calreticulin (ecto-CRT), high mobility group protein B1 (HMGB1), heat shock protein 70 (HSP70), and adenosine triphosphate (ATP) to promote T cells infiltration and transform immunologically cold tumors to hot22–26.