Genes important for metabolic adaptation to diabetes include the transcription factor Clock, playing a role in PT gluconeogenesis and consequent serum glucose concentration in STZ-induced type 1 DM [29], Kdm1, an epigenetic regulator for salt-sensitive hypertension, and the kinases Pik3c2a, Pkn2 [30]. The gene discussed is CLOCK; the disease is diabetes mellitus.