VHL and diabetic kidney disease: To see the impact of Vhl deletion—and subsequent HIF-1α stabilization—on the development of DKD, we analyzed the gene expression profiles of the commonly regulated genes of VHLΔPT & con/STZ & VHLΔPT/STZ mice: ~30% of altered RNA from con/STZ are related to HIF-1α stabilization (overlap of circles, Fig. 3A).