IRS2 and endothelial dysfunction: Among the most increased genes in VHLΔPT compared to control mice from RNAseq data, we identified Skil, Cxcl14, Prox1, Irs2, Nr3c1, Kl, Zbtb20, Tfpi2, and Pfkp which were presented earlier to improve DKD and reduced expression for Bmp4, which was associated with oxidative stress, inflammation and endothelial dysfunction (Supplemental Fig. 4A).