To examine the effects of PT hypoxia reflected as VHL-mediated HIF-1α stabilization in conditions of type 1 diabetes mellitus, we generated mice with deletion of Vhl in the early PT S1/2 segments by cross-breeding Vhlflox mice, termed control (con), with Sglt2cre mice, termed VHL∆PT. The gene discussed is VHL; the disease is diabetes mellitus.