We applied MonsterLM to estimate the GxE variance between three environmental exposures (WHR, days of at least 10 minutes moderate physical activity status [M10], and smoking status) and ten cardiometabolic blood biomarkers (Apolipoprotein A, Apolipoprotein B, Total Cholesterol, CRP, Glucose, HbA1c, HDL-Cholesterol, LDL-Cholesterol, Triglycerides, Total Bilirubin), two cardiometabolic diseases (Coronary Artery Disease [CAD] and Type 2 Diabetes [T2D]), and height. This evidence concerns the gene CRP and coronary artery disorder.