To investigate the role of microglia REV-ERBα on AD-related pathology in vivo particularly tauopathy, we crossed microglia-specific REV-ERBα KO mice with the P301S PS19 human tau transgenic mouse line18, to generate Cx3cr1::Cre+/−; Nr1d1fl/fl; P301S+/− mice and Cre− littermate controls. This evidence concerns the gene MAPT and Alzheimer disease.