PINK1 and Parkinson disease: Excitingly, these phenotypes of PINK1 and Parkin null flies – including crushed thoraces, abnormal wing postures, abnormal mitochondrial morphology in thoraces, increased apoptotic responses in the muscle, impaired climbing ability, and reduced number of DA neurons in the PPM1/2 and PPL1 regions of the adult brain – were fully rescued with CISD KD or KO (Fig. 5a–f and Supplementary Figs. 9a–h, 10a–f, and 11a, b), demonstrating that the suppression of CISD rescues the PD-related pathogenesis induced by PINK1 or Parkin deficiency.