REG1A and colorectal cancer: In order to ascertain why REG1α was highly expressed in colorectal cancer, we exposed HCT116 cells to DNA methyltransferase inhibitor 5-Aza-2’-deoxycytidine (5-Aza), pan histone deacetylase inhibitor Vorinostat (SAHA) or global methylation inhibitor 3-deazaadenosine (DAA) to evaluate the change of REG1α mRNA levels.