Although Glyc-AChE and Glyc-BuChE levels in CSF of AD are confirmed to be positively correlated with the disease duration, and similar to tau, phosphorylated tau, and numerous Aβ proteins, and their levels are significantly higher than those in controls, however, it was found that their levels are not significantly elevated in the early stages of AD [84]. This evidence concerns the gene MAPT and Alzheimer disease.