However, important work shows, first, that LRRK2 kinase activity is increased by PD-driving mutations, and second, that 14 Rab proteins (including Rab3, 5, 8, 10, 12, 29, 35, and 43) are LRRK2 kinase substrates and share a conserved Ser/Thr phosphorylation site (4, 5). This evidence concerns the gene LRRK2 and Parkinson disease.