If we consider LGG, lung squamous cell carcinoma, and acute myeloid leukemia, i.e. three cancer types of disparate scales of miRNA totals for TP53, the commonly responsive miRNAs still occupy substantial portions, most notably accounting for 55% of total 171 TP53-responsive miRNAs in acute myeloid leukemia (Fig. 4C). Here, TP53 is linked to acute myeloid leukemia.