IDH1 and glioblastoma: First, 412 of the total IDH1-responsive miRNAs were linked to known human diseases, and glioblastoma was ranked as the second most relevant disease, claiming 155 disease-related miRNAs (hypergeometric, P = 2.1 × 10−30, false discovery rate 3.6 × 10−28; Fig. 5A).