IDH1 and glioblastoma: Surrounding SOX2, the master regulator of neural stem cell self-renewal that plays a critical role also in glioblastoma stem-like cells (Suvà et al. 2014, Balça-Silva et al. 2017, Singh et al. 2017), we identified 13 miRNAs that were upregulated upon TP53/IDH1/ATRX mutations and anticorrelated with SOX2 transcripts (Fig. 5E).