TP53 and cancer: TP53 is a transcription factor and a famous pan-cancer tumor suppressor gene, mutant IDH1 drives metabolic reprogramming, redox imbalance, and causes genome-wide epigenetic alterations, including impairment of histone demethylation which results in a block to cell differentiation in glioma (Han et al. 2020), and ATRX is a regulator of chromatin remodeling and transcription (Nandakumar et al. 2017).