HLTF and colorectal cancer: Foci of the newly phosphorylated protein, known as γH2AX, is a hallmark of DNA damage associated with a germline HLTF mutation in familial myelodysplastic syndromes (MDS), disease-related depletion of HLTF, epigenetic silencing of HLTF in colorectal cancer and in experimental cell systems from which HLTF has been deleted.