NPPB and obesity due to melanocortin 4 receptor deficiency: Lastly, individuals in phenogroup 5 (“men with SHD and AF”) had the greatest prevalence of mitral and tricuspid regurgitation, as well as the highest NT-proBNP, whereas those in phenogroup 1 (“young men with obesity”) had the lowest NT-proBNP (median levels 3,225 pg/ml versus 1,694 pg/ml, respectively), (Table 2).