In multivariable analysis age, obesity, urea >7.01 mmol/L, and LDH >452.5 U/L were associated with higher risk for in-hospital mortality in patients of both genders, while congestive heart failure (OR 4.83, CI 95% 2.68–8.71) and COPD (OR 4.29, CI 95% 1.44–12.78) were identified as predictors only in male COVID-19 patients, and previous stroke (OR 10.46, CI 95% 2.26–48.32), IL-6 > 69.55 ng/L (OR 2.31, CI 95% 1.23–4.30) and troponin I >18.95 ng/L (OR 2.98, CI 95% 1.64–5.42)–only in female patients. The gene discussed is IL6; the disease is obesity due to melanocortin 4 receptor deficiency.