Coronary artery disease (OR 15.98, 95% CI 1.56–163.93), IL-6 > 69.55 ng/L (OR 4.81, 95% CI 2.06–11.27) were identified as predictors for in-hospital mortality in COVID-19 patients aged 60 years and below, while age (OR 1.05, 95% CI 1.03–1.08), COPD (OR 2.69, 95% CI 1.02–7.11), previous stroke (OR 5.59, 95% CI 2.03–15.35), AST to ALT ratio >1.49 (OR 1.73, 95% CI 1.15–2.58), LDH >452.5 U/L (OR 2.81, 95% CI 1.75–4.49), and CRP > 92.68 mg/L (OR 1.70, 95% CI 1.08–2.70) were also associated with in-hospital mortality in patients older than 60 years old. Here, GPT is linked to chronic obstructive pulmonary disease.