In the innate immune response, DDx58 encodes RIG-I, while MDA5 is an intracellular allosteric RNA monitoring protein and an important member of RLRs family, which recognise cytoplasmic viral nucleic acids and activate downstream cascade signals, leading to the production of IFN-I and pro-inflammatory cytokines in order to resist viral infections, that is the reason why we chose the two genes to analyse [44–46]. Here, IFIH1 is linked to viral infectious disease.