Interestingly, the TCR unresponsiveness characteristics of some chronic autoimmune diseases such as systemic lupus erythematosus have been also associated with the presence of reduced levels of CD3ζ chain (Liossis et al., 1998; Nambiar et al., 2001; Takeuchi et al., 2012; Zhang et al., 2007). Here, CD247 is linked to systemic lupus erythematosus.