These pathways can be pathologically activated by ligand binding (under chronic inflammatory conditions) or by activating mutations within the JAK gene) [53]; There is a plentiful sign that JAK3 protein plays a significant role in lymphocyte maturation and function, and it mostly facilitates and contributes to the creation of cytokines such as IL-2 and IL-4 [54,55]; therefore, the lack or disorder of JAK3 will lead to lymphocyte dysfunction and ultimately lead to immune imbalance. The gene discussed is IL2; the disease is Postural instability.