TNF and neoplasm: In the context of cancer, a single dose of BPA (250 ug/Kg) in newborn Balb/c mice is capable of inducing lung metastasis with increased intratumoral production of IL-1β, IL-6, IFN-γ, TNF-α and VEGF in a model of induced mammary tumorigenesis in which animals were injected in situ with 4T1 tumor cells when they reach sexual maturity [112].