HAGLR, known also as HOXD-AS1, is located between the HOXD1 and HOXD3 genes on chromosome 2q31.1 (Figure 1A) and has been reported to play a critical role in the development and progression of different human cancers, including bladder, cervical, colorectal, gastric, ovarian, prostate, glioma, hepatocellular carcinoma, melanoma, osteosarcoma, and non-small cell lung cancer [38]. The gene discussed is HAGLR; the disease is osteosarcoma.