Specifically, we examined the changes in the mRNA levels of (a) the inflammatory markers S100A8 and S100A9; (b) the inflammasomes NLRP1, NLRP3, NLRP6, and NLRP12, and the inflammasome components inflammasome absent in melanoma (AIM2), apoptosis-associated speck-like protein containing a CAR domain (ASC), and caspase 1 (Casp1) and caspase 11 (Casp11); and (c) the pro-inflammatory mediators IL-1α, IL-1β, IL-6, IL-18, IL-33, and TNF-α. This evidence concerns the gene S100A9 and melanoma.