Although based on a very limited patient number, objective data such as increases in systemic oxygen saturation, serum albumin level, and estimated glomerular filtration rate, as well as a decrease in plasma NT-proBNP-level are promising, as NT-proBNP > 100 pg/mL has a 91% sensitivity for significant ventricular dilation, and one of 82% for ejection fraction <50% [173], and is predictive of adverse outcome [174]. The gene discussed is NPPB; the disease is Ventriculomegaly.