First, MCA205 and TC1 cancers largely failed to respond to treatment with navitoclax and venetoclax when different immune effectors were deficient, as shown for constitutively athymic mice, depletion of T cells in adult mice, the knockout of Batf3 (causing constitutive absence of cDC1 cells), as well as for the depletion of cDC1 cells by Cyt c injections. The gene discussed is BATF3; the disease is cancer.