Compared to universal Xpert Ultra testing, screening with point-of-care CRP was estimated to reduce costs by 54% (total cost: $1.8 million [$1.5 to $2.3 million]) but avert 44% fewer TB-related DALYs (TB-related DALYs averted: 1800 [1400 to 2300]). Here, CRP is linked to tuberculosis.