ACHE and Alzheimer disease: Suwanborirux and coworkers showed that 1 is a potent inhibitor of AChE from the Pacific electric ray, Torpedo californica (IC50 = 91 nM) [5]; approximately six times more potent than galanthamine (4), an alkaloid used in the past for treatment of patients with Alzheimer’s disease (AD) to compensate neurotransmitter deficiency.