PTPN1 and obesity due to melanocortin 4 receptor deficiency: These metabolites have drawn remarkable interest because of their prominent bioactivities, including antioxidant, immunosuppression, antiviral, anti-mycobacterial, antimicrobial, cytotoxic, anti-inflammation, protein tyrosine phosphatase 1B (PTP1B) inhibition, anti-nematode, anti-diabetic, and anti-obesity properties [32,34,37,39,40,41,42,43,44,45,46,47,48].