Peptides previously identified from protein hydrolysates can inhibit enzymes including Angiotensin-Converting Enzyme 1 (ACE-1), Renin, Dipeptidyl peptidase IV (DPP-IV), and cyclooxygenases, which play a part in the development of high blood pressure, type-2-diabetes (T2D), inflammation, and pain, respectively. This evidence concerns the gene REN and type 2 diabetes mellitus.