By loading the TKI Midostaurin onto various types of polymer-coated gold nanoparticles (herein Pluronic and Polyvinylpyrrolidone) we were able to fabricate nanocompounds that can simultaneuously track and neutralise the FMS-like tyrosine kinase 3 (FLT3) in MV4-11 AML cells, without influencing the viability of the control FLT3-negative cells, which is a prerequisite for effective drug clearence. This evidence concerns the gene FLT3 and acute myeloid leukemia.