SPP1 and respiratory system disorder: OPN acts as an organism by playing a pivotal role in the secretion levels of interleukin-10 (IL-10), interleukin-12 (IL-12), interleukin-3 (IL–3), interferon-γ (IFN-γ), integrin αvB3, nuclear factor kappa B (NF-kB), macrophages, and T cells, all organisms involved in respiratory diseases that are outcomes of severe coronavirus disease.