In research provided by Zhao et al., they reported the anti-inflammatory effect presented in UC-MSC-derived exosomes specifically on the granulosa cells in the follicular fluid of the PCOS patients, and it was discovered that TNF-α and interferon-gamma (IFN-γ) were significantly decreased and that IL-10 levels were increased in the PCOS patients [61]. Here, TNF is linked to polycystic ovary syndrome.