SRCAP and Floating-Harbor syndrome: In male probands with delayed growth and bone age, intellectual impairment, skeletal and facial features, and partial responses to hormone treatment, we identified a c.7466C>G (p.Ser2489*) heterozygous pathogenic mutation in the last exon of the SRCAP (Snf2 related CREBBP activator protein) gene, thus suggesting a new model of floating harbor syndrome (FHS) pathogenesis.