Using this approach, we detected rs11863726 in hemoglobin subunit theta 1 (HBQ1), rs328 in lipoprotein lipase (LPL), and rs112984085 in Vav guanine nucleotide exchange factor 3 (VAV3) for T2D and obesity. The gene discussed is LPL; the disease is obesity due to melanocortin 4 receptor deficiency.