Using this approach, we detected rs11863726 in hemoglobin subunit theta 1 (HBQ1), rs328 in lipoprotein lipase (LPL), and rs112984085 in Vav guanine nucleotide exchange factor 3 (VAV3) for T2D and obesity. This evidence concerns the gene VAV3 and obesity due to melanocortin 4 receptor deficiency.