In conclusion, when confronted with a patient experiencing sudden, intense lower abdominal pain, an abdominal CT scan revealing an ovarian tumor accompanied by fluid echoes in both the pelvic cavity and extrapelvic regions, and elevated serum levels of CA125 (>100.9 IU/mL), CA19-9 (>27.7 IU/mL), and CRP (>1.0 g/dL), physicians should maintain a high level of suspicion for a ruptured endometrioma. This evidence concerns the gene CRP and ovarian neoplasm.