Its expression increases with progression from mild to moderate to severe dysplasia, and carcinoma and it may be important as a predictor of adverse outcomes: in fact, also in LSCC, VEGF expression significantly correlates with local recurrence and/or metastases and shorter disease-free survival, especially in locoregionally advanced disease; moreover, it also seems to be a significant predictor of complete response to induction chemotherapy. This evidence concerns the gene VEGFA and carcinoma.