In particular, a Japanese study showed that HLACw12 and HLA-DR15 were significantly associated with anti-CTLA-4 related hypophysitis, whereas HLA-DQB106:01, HLA-DPB109:01, and HLA-DRB5*01:02 were significantly associated with anti-PD-1-related hypophysitis [69]. The gene discussed is CTLA4; the disease is hypophysitis.