PDGFRB and cholesteatoma: Similarly, PDGFr mean ODs were 63.24 ± 3.58 and 37.34 ± 1.64 in congenital cholesteatoma matrix and peri-matrix, respectively (Figure 2(D1,E1)), while a significantly higher PDGFr expression was found in acquired pediatric cholesteatomas, reaching a value of 101.46 ± 5.21 (matrix) and 227.55 ± 9.10 (peri matrix) (Figure 2(D2,E2)).