The effect remained stable in the subgroup (n = 41) of tumor samples with available matched negative controls (EGFR and PTEN r = 0.246, p = 0.009, EGFR and p-mTOR r = −0.207, p = 0.207; p-mTOR and ER r = 0.226, p = 0.014). The gene discussed is ESR1; the disease is neoplasm.