ESR1 and neoplasm: A subgroup analysis of only FIGO II-IV tumor tissue samples with available adjacent negative tissue controls (n = 26) also demonstrated lower p-mTOR (p = 0.048) and ER (p < 0.001) expression levels in tumor samples; differences did not reach statistical significance for EGFR (p = 0.087), PTEN (p = 0.737) and PR (p = 0.102).