SOX17 and pulmonary arterial hypertension: Other reports of childhood-onset PAH included four likely pathogenic variants in a cohort of 2572 PAH cases from a PAH biobank, a report of 12 families [60], and 128 IPAH or HPAH index cases from Japan, in which SOX17 variants were identified in four patients, among whom three patients had ASD or patent foramen ovale [98].