- Obese (vs. lean): ↑ AF inducibility, ↓ APD, ↓ INa expression and current density, ↓ ICa,L expression and current density, ↑ IKur expression and current density, ↑ atrial fibrosis, ↑ F2-IsoPs (↑ oxidative stress), ↑ NOX2 expression, ↑ PKC-α/δ expression- Mitochondrial antioxidant: ↓ AF burden, ↑ INa, ↓ IKur, ↑ ICa,L, ↑ APD, reverse atrial fibrosis. The gene discussed is PRKCA; the disease is atrial fibrillation.