- Obese WT (vs. lean WT): ↑ SGK1 expression, ↑ PACs on continuous telemetry, ↑ AF inducibility, ↔ CV, ↔ APD,- Obese SGK1−/− (vs. obese WT): ↓ AF inducibility, ↓ APD, ↔ INa current density, rightwards/depolarizing shift of INa inactivation kinetics, ↓ atrial fibrosis, ↓ atrial proinflammatory signaling (↓ NLRP3, ↓ IL-1β), ↓ collagen-I expression- Obese SGK1CA (vs. obese WT): ↑ PACs on continuous telemetry, ↑ AF inducibility, ↑ APD, ↑ CV, ↑ NLRP3 expression, ↑ collagen-I expression. The gene discussed is SGK1; the disease is atrial fibrillation.