- Obese WT (vs. lean WT): ↑ LA diameter, ↑ LA fibrosis, ↑ Cad-11 expression in LA, ↑ p-wave duration on ECG, ↓ Cx40 and Cx43 expression, ↑ lateralization of Cx, ↑ AF inducibility, and duration- Obese Cad-11−/− (vs. obese WT): ↓ LA diameter, ↓ LA fibrosis, ↓ expression of proinflammatory cytokines, ↑ Cx40 and Cx43 expression, ↓ AF inducibility and duration. The gene discussed is GJA1; the disease is atrial fibrillation.