- Obese WT (vs. lean WT): ↑ AF inducibility and AF duration, ↓ EP, ↓ APD, ↑ IKur, ↑ calcium leak frequency from SR, ↑ atrial fibrosis- Obese NLRP3−/− (vs. obese WT): ↓ AF inducibility, ↓ IKur, ↓ calcium leak frequency from SR. The gene discussed is NLRP3; the disease is atrial fibrillation.